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Prolozone for Chronic Pain

What causes chronic pain? - The common underlying causes are poor circulation in the area of pain. This leads to local tissue lactic acidosis, which causes the pain we often experience. This becomes a viscious cycle, from poor circulation to lactic acidosis to pain. Trauma produces a localized edema or swelling, and inflammation. This leads to poor circulation in the area of physical trauma, and then poor circulation and pain.

What can cure chronic pain? - The answer is to break this viscious cycle, using interventions that improve local circulation, thereby decreasing acidosis and inflammation, and also eradicating local chronic infeciont, which are epidemic today. This intervention involves the use of local procaine (novocaine) and medical grade ozone injections.


Can it really be this simple? - The injections require training to administer. Dr. Zieve has taken this training several times, has administered these injections to many patients over the past 10 years, and is certified in this method. But it is easy in that all it often requires is procaine and ozone local injections into areas of pain. 

Prolozone is the combination of procaine, combined with a drop of an antiinflammatory steroid, as well as a form of Vitamin B12, then followed by medical grade ozone that is also injected locally. What these injections do is to help cells in the area of pain function better and produce less lactic acid, and improve circulation in local tissues. These two - procaine and ozone- combine to produce lower tissue acidosis, thereby decreasing pain. Ozone by itself stimulates better circulation. 

What can I expect with prolozone injections?

  • Patients not uncommonly experience a decrease in pain, and often a true cure of many chronic injuries and degenerative processes
  • Conditions that respond to prolozone injections: anything associated with pain
  • Chronic back and neck pain
  • Rotator cuff injuries
  • Degenerative  and arthritic knees and hips
  • Degenerated discs
  • Sciatica
  • Sinus infections, acute and chronic
  • Dental infections and pain
  • Scar issues
  • Pelvic disorders in women

The value of prolozone injecitons is that they relieve pain and also correct the underlying pathology that led to pain. About 75% of chronic pain sufferers who undergo this therapy become permanently pain free.

Proloszone is the not the same as prolotherapy.  ( see text description)

How often would I need these injections?

After your first injection (s) it is best to return in 2 weeks to evaluate your pain, and decide if you need another injection. The second visit is generally two weeks after the initial visit for injection(s). It is important to leave 2 weeks between injections for the therapy to work deeply into the tissue. The third visit, if needed, is 2 weeks after the second visit injection. The fourth visit is 4-6  weeks later. People with chronic pain may require” booster” injections every 3-4 months.

What do I do after my prolozone injection?  Ice may be used in the injected area if you experience any discomfort for 15 minutes at least 2-3 times in the first 48 hours after your injection. Most people, in the first 48 hours aftter the first injection, experience some leel of stability, with a 20-80% reduction of pain in a joint or area of injury. Over the first week after your injection, some of the pain may return. The idea is that by the time of your second visit, the level of pain ought to be less. 

Does Chronic Pain Treatment at Partners in Healthcare Naturally involve drug prescriptions?

No. Our treatments, because  they address the underlying causes of chronic pain while at the same time relieveing symptoms, enable people to stop taking any chronic pain medicines that they may have received from other physicians.

Of course, a treatment course for chronic pain may involve suggesting other integrative and naturopathic treatment approaches, such as acupuncture, lasers, botanicals, or other nutrients. Dr. Zieve has taken training from Dr Julia Ross in the use of amino acid therapies in the treatment of chronic pain, and these may be suggested in your program.

If you think you require narcotic or other drug prescriptions for chronic pain, you will need to have these prescriptions filled by another physician, as I do not write prescriptions for any narcotics unless it is in an urgent care acute setting.

Robert Zieve, M.D. 


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